Strong home contingent in New York
Pliskova, facing world No.145 Anhelina Kalinina at the first hurdle, could clinch a second round with France’s Caroline Garcia. Lexington champion Jennifer Brady, No.8 seed Petra Martic and 2016 US Open champion Angelique Kerber will also contest a tricky top quarter.
Scanning down into the second quarter and 2018 champion Naomi Osaka will take to court with compatriot Misaki Doi. An intriguing third round against American protegee Coco Gauff could replicate their 2019 match. They are joined by the likes of sixth seed Petra Kvitova and No.11 seed Elena Rybakina.
The bottom half is packed with Stateside stars, eager for home slam success. Maria Sakkari and Garbine Muguruza will vie in the third quarter with American seeds Serena Williams (No. 3), Madison Keys (No. 7), Amanda Anisimova (No. 22) and Sloane Stephens (No. 26).
2020 Australian Open champion Sofia Kenin bolsters the home ranks in the star-studded fourth quarter. Venus Williams has the tough ask of prevailing past No.20 Karolina Muchova, whilst three-time champion Kim Clijsters enters as a wild card, with No. 21 seed Ekaterina Alexandrova her opening opponent.
Watch out for Aryna Sabalenka (No.5) and Victoria Azarenka booking a second round Belarusian blockbuster.
Women’s popcorn matches
Serena Williams (3) vs Kristie Ahn
Naomi Osaka (4) vs Misaki Doi
Yanina Wickmayer vs Sofia Kenin (2)
Marta Kostyuk vs Daria Kasatkina
Coco Gauff vs Anastasija Sevastova (31)
Johanna Konta vs Heather Watson
Karolina Muchova (20) vs Venus Williams
Kim Clijsters vs Ekaterina Alexandrova (21)
Iga Swiatek vs Veronika Kudermetova (29)
Vera Zvonareva vs Leylah Fernandez