Victoria Azarenka (BLR) [15] v Svetlana Kuznetsova (RUS)
When a pair of two-time Grand Slam champions get together for a first-round tilt at a major, it's time for extra popcorn. Azarenka and Kuznetsova will meet for the 11th time on tour (Azarenka leads 6-4), the third time on clay (Kuznetsova leads 2-1) and the second time at Roland-Garros (Kuznetsova defeated Azarenka in the round of 16 in 2008).
Bianca Andreescu (CAN) [6] v Tamara Zidansek (SLO)
In theory, Bianca Andreescu can be a brilliant clay-courter. She has all the tools - the variety, the feel, the heavy topspin - but lacks the experience.
The Canadian sixth seed will play just her fourth career match on clay against Slovenian dirt-baller Tamara Zidansek, who has won 10 of 14 matches on clay in 2021 (including qualifying).
Nadia Podoroska (ARG) v Belinda Bencic (SUI) [10]
Nadia Podoroska is looking to make a favourable impression in Paris once again in 2021.
The Argentinean was well outside of the top-100 last year when she reached the semi-finals from qualifying. This year she's firmly tucked inside the top-50 and angling for another upset against Swiss No. 10 seed Belinda Bencic.